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Santn-Mrquez et al., 2019), reduce beta-amyloid and tau production (Kim, 2021), increase brain derived neurotrophic factor (Kim et al., 2017), postsynaptic density protein 95, AMPA receptor 1 (GluA1), dendritic spine density (Zhang et al., 2017), and blood brain barrier integrity (Li et al., 2013)

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584 Over a twoyear period, one national study found that impairment in one additional selfcare activity (e.g., bathing, dressing, eating and using the toilet) for those with dementia resulted in 28 additional hours of family care per month

AT004490) and from the US Department of Veterans Affairs (Merit Review no