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In summary, after long-term administration of GLPs, by maintaining glucose and lipid metabolism homeostasis, exerting antioxidative, inflammation-reducing, anti-fibrotic impacts, and regulating gastrointestinal-heart axis, the physiological state and pathological findings in rats remained normal, with no obvious organ damage observed, indicating good safety

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Moreover, following 13 C-glucose tracing in activated Gclc fl/fl and Gclc fl/fl Mb1-Cre + FoB, we detected an increased contribution of glycolytic carbon to lactate within the mutant cells (Fig