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The obvious caveat is that we have only tested GSHee against a 75 mg/kg dose of fentanyl, that while eliciting a substantial degree of ventilatory depression, it does not approach the lethality of higher doses of this opioid

current strategies often disrupt normal mitochondrial function in healthy tissues, and biomarkers to stratify patients likely to respond to such therapies (based on mitochondrial ferroptosis signatures) are still absent