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FUN14 domain-containing protein 1 (FUNDC1), a protein localized on the outer mitochondrial membrane, is associated with mitophagy and mediates the formation of mitochondria-associated endoplasmic reticulum membranes, which can lead to increased cytoplasmic levels of Ca 2+

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26 With several toxic metals lacking robust pathways for elimination or otherwise remaining in the body for along time, body burdens of some toxic metals (eg, lead, mercury, cadmium) may increase with age