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Once activated, GHR signal transduction is downregulated by suppressor of cytokine signaling proteins 13 (SOCS13)

Then the mixture was extracted overnight and centrifuged at 10,000 r/min and 4 C to obtain the supernatant for HPLC analysis

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NMR chemical shift perturbation analysis The CSPs were calculated according to the following equation: where H and N indicate the chemical shift changes of the amide proton and nitrogen, respectively, using CcpNMR 2.5 49