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However, the overall patterns of MS pathology hint at additional routes of propagation discussed below

They are characterized by few caveolae and many mitochondria and generate a high transendothelial electrical resistance (TEER) and low paracellular fluxes

A 2025 IRB-approved pilot study published in PubMed reported no adverse effects following intravenous administration of 20mg in 2 healthy adults, with monitored biomarkers (heart, liver, kidneys, thyroid, and blood glucose) returning normal results

In accordance with this, our results showing that multiple motor features that are indicative of human dystonia are convincingly alleviated in our mouse model of dystonia support cerebellar stimulation for human therapy [63]