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DDR pathway activation phosphorylates and activates p53, which subsequently induces the expression of p21 23

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Tetramethylpyrazine prevents contrast-induced nephropathy via modulating tubular cell mitophagy and suppressing mitochondrial fragmentation, CCL2/CCR2-mediated inflammation, and intestinal injury

In preclinical models, these mechanisms translate into broad potential applications, including wound healing, muscle and tendon repair, gastrointestinal ulcer protection, and recovery from NSAID-induced damage