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Vitamin B12 and folate deficiency can cause a wide range of problems, including: extreme tiredness a lack of energy pins and needles (paraesthesia) a sore and red tongue mouth ulcers muscle weakness disturbed vision psychological problems, which may include depression and confusion problems with memory, understanding and judgement Some of these problems can also happen if you have a deficiency in vitamin B12 or folate but do not have anaemia
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This effect has been documented in corneal studies (Sosne 2011) and in muscular dystrophy models (Spurney 2010, PMC2813286 DMD models)
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