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Notably, chronic stress can trigger epigenetic modifications, reprogramming astrocytes into disease-associated reactive states with distinct molecular profiles compared with normal astrocytes 9,11

Based on these mechanisms, bilirubin demonstrates unique therapeutic potential, offering distinct advantages over established PD treatments

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Autophagy is separated into three types according to the way in which intracellular substrates are transported to lysosomes: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA) 96 (Fig

Therefore, timing plays a crucial role in its effective absorption