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In chondrocyte cultures, GHK-Cu increased the expression of type II collagen, the main structural protein of hyaline cartilage, as well as aggrecan, the most important proteoglycan for the compressive resistance of articular cartilage

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The peptide's biological activity depends entirely on maintaining the chelated copper ion in its Cu oxidation state, bound to the histidine and lysine residues through coordinate covalent bonds

Informed consent was signed by the patient who provided follicular fluid

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