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Dopamine does not cross the digestive and bloodbrain barriers and is rapidly oxidized

Do not use in patients with known hypersensitivity to Hydroxocobalamin or cobalt

Early evidence for the potential efficacy of this route was published in 1999, where 18 patients with B12 deficiency treated exclusively with 712 days of 2 mg of sublingual cobalamin daily had 4 times higher B12 levels compared to pre-treatment, reaching therapeutic ranges ( There have also been further studies comparing treatment outcomes from the sublingual route to the more established IM and oral routes

Medical professionals must evaluate individual health profiles, monitor treatment response, and adjust dosing schedules accordingly

For patients aiming to improve red blood cell production or normalize serum B12 levels, both forms can succeed