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For example, NAD+-dependent enzymes include the sirtuins (SIRT1-7), a family of protein deacetylases involved in gene expression, stress responses, and metabolic regulation, as well as poly(ADP-ribose) polymerases (PARPs) that assist in DNA repair

Following the success and approval of tirzepatide (Mounjaro, Eli Lilly, Indianapolis, IN, USA) in 2022 by FDA for treatment of T2DM, the SURMOUNT programme investigated its use as an anti-obesity medication in those without diabetes

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Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system

These formulations often use microsphere or other sustained-release technologies to extend drug release over weeks or months