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While they found better skin outcomes in participants who used hydroquinone cream (a common melasma intervention), they also concluded that topical silymarin was also effective and produced fewer side effects.28 Wrinkles A lack of skin moisture is one of the factors behind fine lines and wrinkles.29 According to a 2012 study published in the African Journal of Biotechnology , milk thistle extract, emulsified into a topical cream, may help combat wrinkle formation by boosting moisture retention and preventing transepidermal water loss.30 An important caveat to consider is that all of our top recommended milk thistles are oral supplements, and research on oral milk thistle for the above purposes is somewhat lacking

We want you to know that proper care often reverses these conditions

Look for products that combine this with vitamin C, as it enhances glutathione absorption and provides additional brightening benefits

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Cancer Treat Rev 40(1):3140 Dupre-Crochet S et al (2013) ROS production in phagocytes: why, when, and where