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It is important to discuss these risks with a healthcare provider

But in 2006, the companys research institute was sold to GlaxoSmithKline

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Trials will need to follow endocrine shifts, reproductive results, and off-target implications for years, not weeks

In a post hoc analysis after 13 years of the study, a 13% increased risk of vitamin B12 deficiency per year of metformin use was reported (Aroda et al, 2016)