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The authors proposed multiple potential mechanisms including interactions with opioid, GABAergic, and monoaminergic systems, establishing the conceptual framework for subsequent mechanistic research into DSIP's neurophysiological actions

751 obese adults without diabetes were randomized to maximum tolerated doses of tirzepatide versus semaglutide over 72 weeks

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Normal saline (0.9% sodium chloride) Normal saline is occasionally used for peptide reconstitution, but it offers no preservative benefit and can slightly alter the peptide environment compared to bacteriostatic water