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For the quantification of these metabolites in TIF samples, 5 l samples were extracted in 45 l ice-cold extraction solvent (75% acetonitrile, 25% methanol and 0.1% formic acid) containing isotope-labelled internal standards (36 M 13 C 2 , 15 N-GSH, 0.92 M 13 C 4 , 15 N 2 -GSSG and 10 M D 4 -cystine)

AI, alternative preclinical models, and modular global development are shifting decision-making earlier

Combining Multiple Routes An increasingly popular approach is to use multiple delivery routes simultaneously or sequentially

In Brief Some cosmetic ingredients can trigger white patches by injuring pigment-producing cells called melanocytes