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In mitochondria, enzymes involved in the sulfide oxidation pathway, including sulfide:quinone oxidoreductase (SQOR), persulfide dioxygenase (ETHE1) and thiosulfate sulfurtransferase (TST), also contribute to maintaining and regulating intracellular persulfide levels

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A GHK-Cu subcutaneous injection, by contrast, introduces the same molecule into the systemic circulation, where its distribution, its interaction with copper-binding plasma proteins, and its ultimate fate are governed by whole-body copper physiology rather than by local skin diffusion