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For example, administration of the cysteine-donor N-acetyl cysteine (NAC) in humans significantly increases blood [6264] and muscle [65, 66] GSH levels, and in vitro studies show methionine supplementation to have beneficial effects on GSH hepatocyte concentrations [67]

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Overt vitamin B6 deficiency is rare, but approximately 10 percent of Americans may have inadequate B6 status, and it often occurs with deficiencies in other B vitamins like folate and B12

Hydroperoxyl radicals (HO) HO, a form of ROS, forms as an intermediate radical through the protonation of O 2 [50]