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3.4 Effects on other tissues and organs 3.4.1 Renal effects Two randomized trials evaluated the short-term effects of e-cigarette use at the urinary level in former tobacco smokers and current nicotine e-cigarette users (at least 1 year)

Further, green apple flavorant alone can induce a conditioned place preference, in addition to enhancing nicotines rewarding effects, in both male and female adult mice (153, 154), thereby demonstrating rewarding properties on its own

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