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Since preferred nitrogen sources, such as ammonia and nitrogen were not present when proline was used as the sole carbon and nitrogen source, catabolite repression of the proline utilisation pathway ( PUT1 and PUT2 ) would not have occurred 19

These reactions are primarily mediated by UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs), which generate major circulating metabolites such as luteolin-7-O-glucuronide and luteolin-3-O-glucuronide (Xiong et al., 2023)

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Taken together, both syndromes affect 77.8 million children globally, approximately 12% of the worlds 654 million children (05 years) [5, 246]