This ensures that trait-based predictions are grounded in empirically validated causal links and that the three analytical steps of causal inference, sensitivity estimation, and trait-based modeling are logically connected
For example, Bhagot et al
At the end of 2 years, the carcinogenicity of the chemical being studied is assessed by measuring the excess in neoplasm production above background levels of incidence and multiplicity, documenting the occurrence of rare neoplasms with negligible background levels, or demonstrating a reduced latency in neoplasm development in exposed animals versus controls
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