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FIGURE 1 Besides hepatotoxicity, other APAP side effects have also been observed in children

However, to realize its full potential, challenges such as variability in plant composition and lack of standardization must be addressed

10.1007/s00467-010-1627-6 Kumar T, Sharma GS, Singh LR: Homocystinuria: Therapeutic approach

(iv) glutamine polarizes macrophages to M2 phenotype [183] and, as a precursor of glutamate, can also restrain macrophages function, after glutamate-induced N-methyl-D-aspartate receptor (NMDAR) channel activation, leading to tumor development in mouse models of fibrosarcoma and hepatocellular carcinoma [184]