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Less ideal candidates include: Patients who are doing well on standalone semaglutide without significant nausea or body composition concerns
doi:10.1103/PhysRevLett.54.134
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In 1981, for example, a paper published in the International Journal of Clinical Pharmacology, Therapy, and Toxicology described a trial with six volunteers who experienced immediate sleep pressure after intravenous DSIP infusion, as well as increased sleep time, decreased sleep onset, and better sleep efficiency without any sedative effects.13 Three years later, two other human trials across ten test subjects with insomnia found that DSIP administration yielded statistically significant improvements in several key sleep measures fewer sleep arousals, greater sleep efficiency, and increased REM, spindle, and slow-wave sleep.14 The above studies had shortcomings, namely their very small sample sizes, but the sleep-improving effects in cases of insomnia point to DSIPs potential to live up to its name
Researchers interested in the broader comparison between oral and injectable delivery methods will find valuable context in our injectable vs oral peptides comparison page
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