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This, combined with an increase in nicotine per cigarette, resulted in a smoother but also more addictive smoke

However, the use of 3% mepivacaine without epinephrine in inferior alveolar nerve blocks has been found to have a similar anesthetic effect to that of lidocaine with 1:100,000 epinephrine, save for a shorter duration of action, and, as such, this may be considered as an alternative in simple mandibular extractions

A 2008 meta-analysis of 69 clinical trials found that all five nicotine replacement products are superior to placebo, approximately doubling abstinence rates [39]