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Disease-associated glia in neurodegenerative diseases Chronic inflammatory responses and disease-associated glia are well known to contribute to the development of various neurodegenerative diseases

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87 A metaanalysis including 20 published articles describing the frequency of the e4 form among people in the United States who had been diagnosed with Alzheimer's dementia found that 56% had one copy of the APOEe4 gene, and 11% had two copies of the APOEe4 gene