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The method of any one of embodiments 79-143, wherein the therapeutic agent is released from the formulation over a period of at least 14 days

Specific formulations vary by pharmacy and prescriber order

5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD

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