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Comprehensive safety studies spanning six months in rats (up to 100 mg/kg/day) and nine months in cynomolgus monkeys (up to 50 mg/kg/day) revealed no adverse findings, with NOAEL reaching the highest applied dosages

Continuous variables between two independent groups were compared using independent-samples t-tests

Liver tissue sections in WT mice showed massive necrosis in the liver after Con A injection, whereas Gpx1 KO mice injected with Con A showed minor damage

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In breast cancer, the protein fascin promotes treatment resistance by increasing anti-apoptotic protein expression while suppressing pro-apoptotic proteins like caspases-3 and 9 [46] (Fig