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In AD, mitochondrial abnormalities, including impaired electron transport chain function and reduced mitochondrial biogenesis, lead to increased ROS production and diminished ATP generation

"Enhanced recovery of the nigrostriatal dopaminergic system in MPTP-treated mice following intrastriatal injection of genetically modified cells expressing HGF." Journal of Neuroscience Research

The HO-1 increases the expression of super oxide dismutase which can protect against uncoupling of NOS (47-49)

When cholesterol levels decrease, SREBP-2 cleavage activation protein (SCAP) forms a complex with SREBP-2, and this will translocate to the Golgi apparatus where SREBP-2 is cleaved to its active form

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