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The reduction in both the diversity and abundance of gut microbiota compromises microbial defense mechanisms, facilitating pathogenic bacteria invasion of the intestinal mucosa, breaching the intestinal barrier, and triggering immune dysregulation that promotes the development of colitis[72], [73]

Radiat Res 114:114124 Spitz DR, Adams DT, Sherman CM, Roberts RJ (1992) Mechanisms of cellular resistance to hydrogen peroxide, hyperoxia, and 4-hydroxy-2-nonenal toxicity: the significance of increased catalase activity in H 2 O 2 -resistant fibroblasts

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