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Description

NF-B, inflammation, and metabolic disease

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Blocks NNMT in fat cells In 3T3-L1 mouse fat cells, 30 M of 5-Amino-1MQ for 24 hours strongly lowered 1-MNA levels direct proof of NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

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Nitric oxide signalling in kidney regulation and cardiometabolic health

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A change in half-life will not necessarily reflect a change in drug elimination

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