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Initially identified as a stress-responsive protein upregulated during the unfolded protein response (UPR) and ER stress (Mungrue et al., 2009), CHAC1 plays dual roles in cellular regulation

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This overabundance of lactate is associated with a worsened disease state, potentially by creating a pro-inflammatory microenvironment, disrupting the balance of short-chain fatty acid production, and directly impairing epithelial barrier function [130]

doi:10.1016/j.ajpc.2024.100679