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In order to improve the effect of gene therapy in regulating ferroptosis in OA, many studies in recent years have been devoted to optimizing the delivery system to overcome the complexity and barriers of the intra-articular environment (180)

One is through the relationship between calcitriol and ratio of tyrosine to tryptophan hydroxylase

These molecules, in excess, can cause an imbalance in our body, leading to a state of oxidative stress

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for the sterilization process and to temperatures of at least 230-250 C