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Selective NNMT inhibitors (including 5-Amino-1MQ) lower 1-MNA, increase NAD and SAM, suppress adipocyte lipogenesis, and reverse HFD-induced obesity in mice [1]

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Another (very small study) found that combining biotin with a probiotic supplement, alongside a targeted topical gel appeared to safely reduce acne and improve skin health over 2 months in people with mild to moderate acne

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