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doi: 10.1006/taap.2002.9420 45 NebertDWDaltonTP

Istradefylline: Istradefylline offers a novel non-dopaminergic adjunct therapy to LD for managing OFF episodes in individuals with moderate to severe PD [109]

That is not a fringe concern it is the explicit worry of experienced former FDA officials who have spent careers building the evaluation standards that protect patients