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The 2-OH-E1 route catalyzed by CYP1A1 is a stable route, and it can be easily metabolized further through methylation, which is accomplished by catechol-O-methyltransferase (COMT)

doi: 10.12944/CRNFSJ.8.1.08 9 CaasR

However, many people suffer from Vitamin B12 deficiency due to various reasons, including poor dietary intake, absorption issues, or certain medical conditions

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Conversely, defective autophagy exacerbates inflammatory responses, further aggravating insulin resistance in women with PCOS ( 3.3 Ferroptosis Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, may play a key role in the pathogenesis of PCOS