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also suggests that the peptide may upregulate VEGF, increase endothelial cell proliferation, and promote endothelial migration and tube formation

This gastric stability fed the hypothesis of oral bioavailability, a hypothesis nevertheless difficult to rigorously validate because animal studies predominantly use intraperitoneal or subcutaneous routes

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Skorjanec S, Kokot A, Drmic D, et al

Takeaway: What you should worry about is shaped by land use, source type, and eventsnot just by whether water is treated. Is bottled water, alkaline water, or RO automatically safer than tap water (and why demos like red dye tests mislead)