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Pharmacokinetics: Cyanocobalamin is administered intranasally, orally, and parenterally, while hydroxocobalamin is administered only parenterally. Once absorbed, vitamin B12 is highly bound to transcobalamin II, a specific B-globulin carrier protein and is distributed and stored primarily in the liver as coenzyme B12. The bone marrow also stores a significant amount of the absorbed vitamin B12. This vitamin crosses the placenta and is distributed into breast milk. Enterohepatic recirculation conserves systemic stores. The half-life is about 6 days (400 days in the liver). Elimination is primarily through the bile; however, excess cyanocobalamin is excreted unchanged in the urine

Before the shot I had no energy whatsoever

Estrogen levels are key in B12 metabolism

General subcutaneous injection at distant sites like the abdomen can still provide systemic benefits, just potentially with a slower onset for the specific shoulder condition

Sixteen breastfeeding mothers suspected of B12 deficiency were given a B12 injection of 50 g