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While ad libitum (AL)-fed mice eat in multiple small bouts throughout the day, with most of the intake during the night, CR regimens are performed by feeding mice only once-per-day

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Much of the mechanism evidence comes from lab and animal studies

This is especially true if someone has already been diagnosed with vitamin B12 deficiency, which is most likely to affect vegetarians/vegans, older adults and people with malabsorption issues due to underlying health conditions