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Certain symptoms require escalation , including severe or worsening pain, progressive weakness, or changes in bowel or bladder function

doi: 10.1007/s00424-020-02417-x

Web of Science, PubMed, and Cochrane Library from September 2018 to June 2020 were systematically searched by two investigators, and the published date for searched papers from the databases ranged from June 1990 to June 2020

Since few years, targeted therapies emerged as a promising senolytic approach, and several molecules are under clinical evaluation

Additionally, its neuroprotective capabilities are under investigation for the potential treatment of neurodegenerative disorders such as Alzheimer's, Parkinson's disease, and stroke, by shielding brain cells from injury [[158], [159], [160]]