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The procedure involves harvesting a small sample of healthy cartilage from a non-weight-bearing area, isolating and expanding chondrocytes ex vivo , and implanting them into the cartilage defect, often under a periosteal flap or collagen membrane (Welch et al., 2016

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A comprehensive preclinical study compared four different transplantation routes: intraportal injection, intrahepatic artery injection, intravenous injection and intrahepatic injection