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These gaps highlight the need for future research to move beyond descriptive associations toward systematic dissection of ferroptosis initiation mechanisms, cell type-specific contributions, and clinical validation

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doi: 10.3389/fphar.2025.1526270 Received 11 November 2024 Accepted 28 January 2025 Published 17 February 2025 Volume 16 - 2025 Edited by Alessandra Linardi, Santa Casa de So Paulo School of Medical Sciences, Brazil Reviewed by David Pubill, University of Barcelona, Spain Ariadiny Lima Caetano, Santa Casa de So Paulo School of Medical, Brazil Updates Copyright 2025 Wang, Hao, Ma, Feng, Yang, An, Su and Feng