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Although different TLRs recognize distinct ligands, all TLRs share a conserved cytoplasmic domain named Toll/interleukin (IL)-1 receptor (TIR) domain, which mediates downstream signaling by recruiting specific adaptor proteins, including TIR domain-containing adaptor molecules to receptors

[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Muteliefu G., Enomoto A., Jiang P., Takahashi M., Niwa T