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This is a warning for all practitioners, as antibiotics may be overused in advanced skin tumors. Though limited by its retrospective design, the study reinforces a call for prospective trials examining microbiota modulation strategiessuch as antibiotic stewardship, bacterial profiling, or even microbiome restorationto enhance ICI outcomes

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Am J Otol 14:301305 Rights and permissions About this article Cite this article Lee, S.H., Jin, S.M., Lee, K.C