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It is worth noting that these investigators began VPA 48 h before infusion of epirubicin on each cycle to attempt to exploit synergism seen with this sequencing approach demonstrated in pre-clinical models (see below)

Research to date suggests it is generally well tolerated, with no serious adverse events reported during short- to mid-term use

Also, a genetic component in NTD etiology is evidenced by the increased risk in women with a family history of an NTD and also by variations in risk among ethnicities (44)

Owing to the heterogeneity and individual differences in aging, current clinical drugs cannot precisely target senescent cells and have frequent off-target effects, resulting in poor clinical efficacy