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Notably, rational design of a single amino acid substitution in wild-type AtCOMT, guided by AlphaFold3 structural modeling, resulted in a remarkable 40-fold increase in 5-MeO-DMT 10 production in N

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(Reviews, by the way, are basically summaries of the research produced on a topic that often assess how conclusive the body of evidence is.) Relying primarily on publicly funded work published since 2020, heres what I found

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