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Research reveals that TMAO activates the PERK signaling pathway in zebrafish liver and HepG2 cells, inducing pathological alterations including lipid accumulation, inflammation, and fibrosis (Yang et al., 2024)

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Currently, however, there is a severe lack of human clinical data to support these claims, and fewer than five human trials are indexed in major databases, most with small sample sizes or unclear methodologies

El Osta, R., Grandpre, N., Monnin, N., Hubert, J