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reported elevated levels of Pan-Kla and H4K12la in the cortex and hippocampus of 5XFAD mice, showing significant co-localization with microglia [70]

Fluorescence intensity decreased in both the HG and BHG groups, with the lowest ROS levels observed in the BHG group

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Its mechanism involves modulation of the hypothalamic-pituitary-adrenal (HPA) axis, regulation of cortisol and growth hormone-releasing hormone (GHRH) secretion, and interaction with the GABAergic and glutamatergic systems