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In the context of tinnitus, bioinformatic studies of synaptic transmission in spiral ganglion neurons have identified GDNF as a key protein, with proteinprotein interaction networks highlighting its role alongside BDNF in processes related to the perception of sound (Gross et al., 2023)

It also increases the likelihood of developing hypertension, kidney damage, albuminuria, and chronic kidney disease (CKD), ascribed to the death of nephrons and subsequent hyperfiltration in the surviving nephrons (50, 51)

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Insulin, which promotes glucose uptake and utilization, can enhance the flux through the PPP, particularly in tissues like the liver and adipose tissue where lipogenesis is active