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Introduction Rheumatoid arthritis (RA) is a common chronic inflammatory disease and systemic autoimmune disease, mainly involving the synovial joints, and is characterized by destroyed immune regulation of the joint synovial membrane, systemic inflammation and the existence of autoantibodies, which finally lead to severe damage and destruction of cartilage and bone ( Polyphenols Resveratrol Resveratrol (RES) (3,5,4-trihydroxystilbene) is a natural antioxidant that exists in a variety of plants, such as Cassia obtusifolia, Veratrum nigrum, Polygonum cuspidatum, grapes, soybeans and nuts, and has a variety of pharmacological effects, as well as therapeutic effects on a variety of autoimmune diseases, including RA ( The research by Buhrmann C et al
Sengupta et al., 2024
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There is also pressure from animal welfare groups to move away from in vivo testing towards in vitro testing (outside the animal), where just its cells or blood samples are used in the evaluations making it not fatal to the test animal
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