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Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis

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It should also be noted that significant quantities of O 2 - are produced in the reactions catalyzed by iNOS, and O 2 - reacts with NO to generate peroxynitrite (ONOO ) with strong oxidizing and nitriding properties (95)

The first hitsuch as infection or toxin exposuremay establish a state of susceptibility, with exercise acting as the second hit that ignites the potential pathological cycle